abstract：:Following a 3 hour in vivo labelling of cytoplasmic RNA in rat liver with orotic acid-6-14C under conditions where ribosomal RNA synthesis was suppressed, the proportion of labelled messenger-like RNA released to the cytoplasm which contained polyadenylate (poly(A)) tracts was about 3.0 times higher in the livers of j...

journal_title：Mechanisms of ageing and development

authors： Yannarell A,Schumm DE,Webb TE

更新日期：1977-07-01 00:00:00

abstract：:The protein synthesizing capacity of liver parenchymal cells isolated from 3-, 12-, 24-, 31- and 36-month-old rats was determined by the incorporation of 14C-leucine. Conditions for optimum protein synthesis included the use of an enriched medium (modified Waymouth's MB 752/1) and cell suspension concentrations rangin...

journal_title：Mechanisms of ageing and development

authors： Van Bezooijen CF,Grell T,Knook DL

更新日期：1977-07-01 00:00:00

abstract：:A comparison is made between how bacteria and men use their DNA to accomplish any major biological function. To make this comparison, a modified cybernetic analysis was used. This new type of cybernetic analysis makes a distinction between controlled and regulated systems and may permit an extension of cybernetics int...

journal_title：Mechanisms of ageing and development

authors： Denckla WD

更新日期：1977-03-01 00:00:00

abstract：:Women enjoy a superior longevity, possibly at the price of a heavy loss of female conceptuses at an early stage of gestation. An immunological mechanism is proposed. A theory of selection at implantation is developed and generalized which leads to a new approach of longevity. ...

journal_title：Mechanisms of ageing and development

authors： Vernier MC

更新日期：1977-01-01 00:00:00

abstract：:Cyclic AMP levels and activities of adenylate cyclase and phosphodiesterase in the striatum were measured in 4, 12, 24 and 30 month-old rats. No age-related changes were observed either in cyclic AMP levels or basal adenylate cyclase activity. However, there was an age-related decline in dopamine sensitivity of adenyl...

journal_title：Mechanisms of ageing and development

authors： Puri SK,Volicer L

更新日期：1977-01-01 00:00:00

abstract：:Long-Evans female rats three weeks, three months and 13-14 months of age were placed on tryptophan-deficient diets for periods ranging from a few months to nearly two years. Growth was interupted during the period of tryptophan-deficiency, but when the animals were returned to a complete diet, they gained weight and g...

journal_title：Mechanisms of ageing and development

authors： Segall PE,Timiras PS

更新日期：1976-03-01 00:00:00

abstract：:To investigate the relationship between immunological potential and advance of age, patterns of humoral immune response in different aged rabbits were compared. In the primary response, the appearance of total antibody and the arrival to its peak level were retarded by advance of age. On the other hand, the appearance...

journal_title：Mechanisms of ageing and development

authors： Nomaguchi T,Okuma-Sakurai Y,Kimura I

更新日期：1976-01-01 00:00:00

abstract：:This paper is part of a series aimed to investigate the mechanism of the action of Folcysteine, a substance that has the capacity to release in the body active -SH groups and has been proved to be effective in the control of menopausal troubles. As an experimental model the ovariectomized rat, rather similar, from the...

journal_title：Mechanisms of ageing and development

authors： Moldoveanu E,Klein R,Bartoc R,Bruhis S,Oeriu I

更新日期：1975-09-01 00:00:00

abstract：:One to 24 month old rats were anesthetized with alpha-chloralose, their cerebral cortices exposed surgically and subjected in vivo to stimulation by norepinephrine (1.0mM for 5 minutes) or electrical pulses (100 pulses/s for 10 s). After microwave fixation, cortical samples were analyzed for cyclic-AMP by the Gilman m...

journal_title：Mechanisms of ageing and development

authors： Berg A,Zimmerman ID

更新日期：1975-09-01 00:00:00

abstract：:The effect of various immunosuppressive treatments on mean life-span and disease incidence have been studied. Significant life shortening was seen only in mice which recieved X-irradiation early in life and can be ascribed primarily to an increased incidence of certain malignancies. Marginal life shortening was seen i...

journal_title：Mechanisms of ageing and development

authors： Peter CP,Perkins EH,Peterson WJ,Walburg HE,Makinodan T

更新日期：1975-05-01 00:00:00

abstract：:Exposure of Drosophila melanogaster adult males to an atmosphere of O2-N2 (1:1) at 760 Torr resulted in a marked reduction of life span. Among the fine structural changes occurring in the oxygen-poisoned flies, the following were similar to age-related changes: ceroid-lipofuscin accumulation in the visceral organs, sp...

journal_title：Mechanisms of ageing and development

authors： Miquel J,Lundgren PR,Bensch KG

更新日期：1975-01-01 00:00:00

abstract：:The decline in phytohemagglutinin (PHA) responsiveness of spleen cells from aged mice was studied in an effort to determine the nature of the depressed PHA reactivity. The reduced response of DNA synthesis (thymidine incorporation) to PHA stimulation could not be attributed to a decreased viability of spleen lymphocyt...

journal_title：Mechanisms of ageing and development

authors： Hung CY,Perkins EH,Yang WK

更新日期：1975-01-01 00:00:00